This document is only valid for the day on which it is accessed. Please read our disclaimer.
This is a restricted antibiotic and requires approval for use from the Infectious Disease team. It is used for:
- Treatment of serious gram positive infections
- Serious infections due to methicillin-resistant staphylococcus aureus (MRSA).
- 15mg/kg IV every six hours
- Usual maximum daily dose - 2grams. Higher doses may be used in certain cases. Please consult ID team or pharmacy for further advice on dosing
- For dosing in neonates refer to Newborn guidelines
- Doses must be reduced in patients with renal dysfunction.
- Administer via peripheral or central line
Trough levels only- take trough immediately before the next dose.
Approximate time to reach steady state is 1-2 days, check trough initially after 3-5 doses then every 3 to 5 days if satisfactory level and normal renal function
Aim for trough: 10mg-15mg/L, up to 20mg/L in certain cases.
Monitor serum electrolytes and creatinine (check for renal toxicity)
Further Reading/Associated Documents
Did you find this information helpful?
- Date last published: 01 October 2013
- Document type: Clinical Guideline
- Services responsible: Paediatric Infectious Diseases
- Author(s): Emma Best
- Editor: Greg Williams
- Review frequency: 2 years
SIGN UP TO RECEIVE GUIDELINE UPDATES
Subscribe below if you want us to let you know about new or updated guidelines
More From Starship
We welcome your involvement. Find out what guidelines are currently in development or under review. Find out more...
Read about the governance process around the Starship Clinical Guidelines and how to format guidelines in development.