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Gastrointestinal bleeding is an uncommon but important sign in paediatric patients.
Patients with acute significant blood loss will need urgent IV access and resuscitation. Refer to guidelines for CPR and/or Shock
Tachycardia is an important sign of hypovolaemia in paediatric patients with blood loss
There are many causes of GI bleeding in children.
Important factors that help determine aetiology and focus interventions include:
- Site of bleeding
- Age of onset
- Presence of abdominal pain
- Presence of diarrhoea
- Personal or family history of atopy or food allergy
NB: For patients with liver disease see Chronic Liver Disease Complications in the ADHB policies and guidelines library
Site of Bleeding
Non GI mimics of GI blood loss
Epistaxis, maternal blood, dental work, haemoptysis. Substances such as iron, beetroot, spinach and blueberries can mimic melaena
(mouth to the ligament of Treitz, the 2nd part of the duodenum)
- Haematemesis (vomited blood)
- Bright red suggests active bleeding
- Altered blood - may be black (resembling coffee ground) suggests less active bleeding
- Upper GI blood loss may present as melaena
|Oesophagus||Mallory-Weiss tear||Repeated vomiting|
|Oesophageal varices||Stigmata of chronic liver disease or portal hypertension|
|Foreign body||Including possible button battery ingestion|
|Stomach||H. pylori peptic ulcer|
|Non-helicobacter gastritis||Non steroidal anti-inflammatory use|
|Small intestine||H. pylori/peptic ulcer|
|Haemolytic uraemic syndrome||Elevated urea|
|Arteriovenous malformation||Cutaneous A-V malformations|
|Crohn's disease||Weight loss, diarrhoea|
(distal to the ligament of Treitz)
- Melaena (black, tarry odiferous stool) suggests blood proximal to ileo-caecal valve
- Haematochezia (bright red blood per rectum) generally indicates a colonic site of bleeding. Occasionally red blood in the stool may originate from the small intestine as a result of rapid gut transit.
- Constipation (possible anal fissure)
- Diarrhoea (inflammatory bowel disease/ infectious causes Salmonella, Campylobacter, Shigella, entero-invasive E.coli and Yersinia)
- Recent antibiotic exposure (clostridium difficile)
- In infants with a personal or family history of atopy or food allergy (breast and formula fed) (allergic proctocolitis)
- Liver disease (oesophageal varices and vitamin K deficiency)
- Bleeding disorders
- Cystic fibrosis (oesophageal varices and vitamin K deficiency)
- Medication exposure NSAIDs (gastritis) and prior antibiotic exposure (pseudomembranous colitis)
- Overseas travel (infectious)
- Family medical history (peptic ulcer disease, bleeding disorders, inflammatory bowel disease, polyposis syndrome. Other sick contacts may indicate an infectious cause)
- Hypotension is a late and ominous sign in GI bleeding
- Orthostatic hypotension (a rise in the pulse rate by 20 beats per minute or a fall in the systolic blood pressure of more than 10mmHg indicates significant volume depletion, usually > 20%).
- Abdominal tenderness suggesting a surgical cause of pain, haemolytic uraemic syndrome, gastric/ duodenal ulceration
- Anal fissure - constipation
- Anal skin tags suggesting Crohn's disease.
- "Haemorrhoids" are an uncommon in paediatric and adolescent patients. Anal skin tags are a common mimic of "haemorrhoids". Presence of true anal varicosities suggest portal hypertension.
- Stigmata of liver disease (hepatosplenomegaly, jaundice, cutaneous purpura, spider naevi, clubbing, ascites)
- Cutaneous haemangiomata may indicate the presence of GI mucosal haemangiomata.
- Pigmentation of the lips and buccal mucosa may suggest Peutz-Jeghers syndrome.
- Purpura on the buttocks and lower extremities are characteristic of Henoch Schonlein Purpura.
- FBC A recent bleed may not initially alter the haemoglobin or haematocrit . The MCV can be low in chronic low grade bleeding. Raised eosinophils may signify an allergic colitis. Low platelets suggest hypersplenism or idiopathic thrombocytopaenia.
- ESR/ CRP - may indicate inflammatory bowel disease or sepsis
- Coagulation profile to rule out a liver disease, bleeding disorder or disseminated intravascular coagulopathy.
- Liver function tests if there are signs of portal hypertension or chronic liver disease.
- Stool cultures and a C-difficile toxin assay if there are loose stools.
- Renal function tests
A high urea may be a clue for haemolytic uraemic syndrome or may indicate the presence of dehydration.
A high urea may also be due to resorbed blood in the upper GI tract
- H.pylori stool antigen is not recommended as H.pylori is prevalent in the general paediatric population and is not usually associated with morbidity. H.pylori complications are diagnosed endoscopically.
Fibreoptic endoscopy and biopsy has increased the rate of positive diagnosis. The yield decreases if endoscopy is delayed, so it is important that endoscopy occurs promptly. Preparation of the patient is critically important. In emergency situations where bleeding is severe, resuscitation of the patient is paramount. Endoscopy should not be performed hastily if the patient is unstable.
Upper GI bleeding
Significant upper GI bleeding requires endoscopy for investigation. Contrast studies should not be the initial study to rule out oesophagitis, gastritis or peptic ulcers because of the lack of sensitivity. Contrast studies may be indicated in patients with dysphagia or odynophagia. Ultrasound should be requested if there is evidence of liver disease or splenomegaly.
Lower GI Bleeding
Colonoscopy is the best test for significant lower GI bleeding. An exception is suspected intussusception, where ultrasound should be requested (and if confirmed, an enema for reduction).
Painless rectal bleeding
A Meckel scan is the procedure of choice. CT angiography may also help localize bleeding for AV malformations
Obscure bleeding in the GI tract
Capsule endoscopy may provide a diagnosis in some cases.
- If there is significant bleeding:
- 2 large bore IV lines
- re-establish blood volume (rapid infusion of 0.9% NaCl +- by red cells).
- Acid suppression: Omeprazole (2mg/kg/day). Patients < 7 years should receive q12hourly dosing.
- Urgent referral to appropriate teams PICU/ Surgery/ General Paediatrics/ Gastroenterology
- Significant GI bleeding requires admission for observation +/- ongoing investigation and treatment.
- Never discharge a patient with liver disease and GI bleeding unless discussed with on-call Paediatric Gastroenterologist/Hepatologist.
emedicine Paediatics. Gastrointestinal Bleeding. R Y Hsia, J Halpern, O L de Mola updated Dec 8, 2009
Vinton N. Gastro-intestinal bleeding in infancy and childhood. Gastroenterol Clin North Am. 1994; 23: 93-122.
Ament M. Diagnosis and management of upper gastro-intestinal bleeding in the paediatric patient. Pediatr Rev 1990; 12: 107-116.
Siafakas C, Fox V, Nurko S. Use of Octreotide for the treatment of severe gastro-intestinal bleeding in children. J Pediatr Gastroenterol Nutr. 1998; 26: 356-359.
Treem W. Gastro-intestinal bleeding in children. Gastrointest Endosc Clin North Am 1994; 4: 75-97.
Molleston J. Variceal bleeding in children. J Pediatr Gastroenterol Nutr 2003; 37; 538-545.
Did you find this information helpful?
- Date last published: 12 April 2016
- Document type: Clinical Guideline
- Services responsible: Paediatric Gastroenterology/Hepatology
- Author(s): Simon Chin, Stephen Mouat
- Editor: Greg Williams
- Review frequency: 2 years
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