Immunodeficiency - basic tests
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Immune deficiency may present with recurrent infections but the initial presentation can also be with a severe infection which may be fatal. If an infant or young child presents with a life threatening infection and death is imminent/likely, consideration should be given to a limited immune screen.
Suggested investigations in seriously ill/dying infants and young children in whom underlying immune deficiency is possible are listed below.
Table 1: tests and sample requirements
|Test for||Sample required|
|Blood count||EDTA 250uL|
|Serum IgG, IgA, IgM and IgE||Serum 500uL|
|HIV serology||Serum 500uL|
|Lymphocyte phenotype||Heparin 500uL|
|TREC (in infants under 12 months)||EDTA 500uL|
|DHR (replaces previous NBT)||EDTA 500uL|
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- Date last published: 24 August 2012
- Document type: Clinical Guideline
- Services responsible: Paediatric Intensive Care Unit
- Owner: Fiona Miles
- Editor: John Beca
- Review frequency: 2 years
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